Thursday, September 04, 2008

Obama: Yes to stem cells, funding

Declan was told by a scientist on Tuesday that he hadn't received any email with the subject "NAC: Petition to the UN on Therapeutic Cloning", not even in his spam box – Declan usually makes three or four random calls, although normally all he gets are voice mails. So it seems that a spam box is too good for Declan's email: scientists and academics can spot it among the junk and decide to sign the petition. It might explain why there were no signatures yesterday despite me emailing 105 scientists; the day before I emailed 139.

Democratic presidential candidate Barack ObamaDemocratic presidential candidate Barack Obama

If elected President of the United States in November, Democratic presidential candidate Barack Obama says he will lift the Bush administration's ban on federal funding of research on embryonic stem cell lines created after 9 August 2001, and ensure that all research on stem cells is conducted ethically and with rigorous oversight. Obama recently answered a fourteen-part questionnaire posed to him and Republican presidential candidate John McCain by the grassroots group Science Debate 2008, which says it hopes to make key science issues a larger part of the election. McCain has said he will also answer the questions.

The questionnaire was a joint effort of Science Debate 2008, Scientists and Engineers for America, the American Association for the Advancement of Science, the National Academies (the National Academy of Sciences, National Academy of Engineering, Institute of Medicine and National Research Council), the Council on Competitiveness and others, together representing more than 125 million voters. The questions dealt with a range of topics including genetics, stem cell research, scientific integrity, and research. "Most of America's major unsolved challenges revolve around these 14 questions," Shawn Otto, chief executive officer of Science Debate 2008, said in a statement. "To move America forward, the next president needs a substantive plan for tackling [the issues] going in, and voters deserve to know what that plan is."

Obama's answer to the question on embryonic stem cell research (Q: "Stem cell research advocates say it may successfully lead to treatments for many chronic diseases and injuries, saving lives, but opponents argue that using embryos as a source for stem cells destroys human life. What is your position on government regulation and funding of stem cell research?") is reproduced here:

Stem cell research holds the promise of improving our lives in at least three ways – by substituting normal cells for damaged cells to treat diabetes, Parkinson's disease, spinal cord injury, heart failure and other disorders; by providing scientists with safe and convenient models of disease for drug development; and by helping to understand fundamental aspects of normal development and cell dysfunction.

For these reasons, I strongly support expanding research on stem cells. I believe that the restrictions that President Bush has placed on funding of human embryonic stem cell research have handcuffed our scientists and hindered our ability to compete with other nations. As president, I will lift the current administration's ban on federal funding of research on embryonic stem cell lines created after August 9, 2001 through executive order, and I will ensure that all research on stem cells is conducted ethically and with rigorous oversight.

I recognize that some people object to government support of research that requires cells to be harvested from human embryos. However, hundreds of thousands of embryos stored in the U.S. in in-vitro fertilization clinics will not be used for reproductive purposes, and will eventually be destroyed. I believe that it is ethical to use these extra embryos for research that could save lives when they are freely donated for that express purpose.

I am also aware that there have been suggestions that human stem cells of various types, derived from sources other than embryos, make the use of embryonic stem cells unnecessary. I don't agree. While adult stem cells, such as those harvested from blood or bone marrow, are already used for treatment of some diseases, they do not have the versatility of embryonic stem cells and cannot replace them. Recent discoveries indicate that adult skin cells can be reprogrammed to behave like stem cells; these are exciting findings that might in the future lead to an alternate source of highly versatile stem cells. However, embryonic stem cells remain the "gold standard," and studies of all types of stem cells should continue in parallel for the foreseeable future.

Rather than restrict the funding of such research, I favor responsible oversight of it, in accord with recent reports from the National Research Council. Recommendations from the NRC reports are already being followed by institutions that conduct human embryonic stem cell research with funds from a variety of sources. An expanded, federally-supported stem cell research program will encourage talented U.S. scientists to engage in this important new field, will allow more effective oversight, and will signal to other countries our commitment to compete in this exciting area of medical research.

A recent article in the News-Journal, titled "East Texans find success in stem cell treatments", quoted Kevin Wilson, director of public policy for The American Society for Cell Biology, as saying that US Food and Drug Administration officials are cautious about allocating research money toward embryonic stem cell research, and that the government is losing billions of dollars in research time and money by stalling on embryonic stem cell research. "The president's policy puts stem cell research in a time warp," Wilson said. "In Singapore, stem cell research accounts for about $5 billion of its economy, and the country has invested billions into the research as well. We must have the US policy overturned."

Besides the hotly contested presidential election, Michigan voters will vote in November on a ballot proposal that would loosen restrictions on embryonic stem cell research. Medical News Today reports that the official wording of the ballot measure says that it will expand use of human embryos for any research permitted under federal law subject to the following limits: the embryos are created for fertility treatment purposes; are not suitable for implantation or are in excess of clinical needs; would be discarded unless used for research; were donated by the person seeking fertility treatment; provide that stem cells cannot be taken from human embryos more than 14 days after cell division begins; prohibit any person from selling or purchasing human embryos for stem cell research; and prohibit state and local laws that prevent, restrict or discourage stem cell research, future therapies and cures. It also quotes Joe Schwarz, a physician and former Republican member of Congress who heads the Cure Michigan campaign, as saying: "What we are talking about here is providing cures for people, providing therapies for people. In this century, a majority of therapies and cures will be from genetic therapy and cellular therapy and not from popping chemical compounds, which is what we've done all our lives. So this is a movement forward."

Right now Michigan is one of only five states to ban the use of discarded embryos for medical research (the others: South Dakota, North Dakota, Louisiana and Arkansas), but not everyone wants to see things change. The Michigan Catholic Conference, which has joined the ballot question committee Michigan Citizens Against Unrestricted Science and Experimentation (MiCAUSE), states on their homepage that the proposal "would amend the state constitution to allow for unregulated, unrestricted embryo destruction in Michigan. The proposal also opens the door for human cloning to become legal in this state." In contrast, a letter of support for the ballot initiative to support embryonic stem cell research was issued only yesterday by the International Society for Stem Cell Research (ISSCR), an independent, nonprofit organisation which represents over 2,600 leading stem cell researchers from around the world, stating: "The ethical safeguards proposed under Michigan's ballot initiative would provide an ethical framework within which important medical research could go forward."

Melvin Lester, Adjunct Professor of Medicine and President of Michigan Citizens for Stem Cell Research and Cures spoke at the House Judiciary Committee hearing in November 2007: "Do as you please. Don’t participate in embryonic stem cell research if it is against your better judgment, but please don’t tell us that the citizens of forty-five of our states that permit, endorse and support embryonic stem cell research are unethical, immoral and murderers. The majority of the citizens of Michigan like the majority of the citizens of the United States want this law rescinded."